Endocrine Abstracts

Introduction: Neurofibromatosis type 1 (NF1) is the most common type of NF, and accounts for about 90% of all cases. Primary empty sella syndrome (ESS) results from herniation of arachnoid mater into the pituitary fossa. Since it has been demonstrated that the small anterior pituitary size reflects loss of neurofibromin expression in the hypothalamus, leading to reduced GHRH, pituitary GH and IGF1 production, we agree that IGF1 and GH increased in our patient can be challengin...